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this classification can be reviewed and is subject to change in future WADA cycles

That difference is a significant, sometimes dramatic shift for peptide stability

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The key distinction: MOTS-c acts as a signaling molecule that tells cells what to do with energy substrates

The modern biochemical exploration of metabolic syndromes, cellular energy expenditure, and skeletal muscle regeneration relies extensively on small molecules capable of modulating intracellular enzyme activity

doi: 10.1378/chest.07-2134